Results of several clinical trials(1-9) studying  the cord blood cell intravenous infusion treatment of ischemic stroke have been published in scientific literature since 2012. The effect of the treatment has been studied mostly on children with cerebral palsy(1,2,3,5,6,7,8) in majority caused by ischemic stroke during labor and delivery. One study has been conducted on adult patients after ischemic stroke(4). Some studies have used autologous cord blood(3,7,8), others have used allogeneic cord blood(1,2,4,5,6,9). All have shown trend or significant improvement in motoric and cognitive functions of the patients.

One study has shown clinical improvement after repetitive treatment 3-6 and 6-12 months after the first treatment(6).

In Most of the studies patients have undergone the treatment several years after the ischemic stroke event(1,2,3,4,6,7,8,9). The only study conducted on adults has included patients up to 10 days after the ischemic stroke event(4).

Clinical Trials:

1. Feng, Mei et al. “Safety of Allogeneic Umbilical Cord Blood Stem Cells Therapy in Patients with Severe Cerebral Palsy: A Retrospective Study.” Stem cells international vol. 2015 (2015): 325652. doi:10.1155/2015/325652
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510256/

2. Kang, Mino et al. “Involvement Of Immune Responses In The Efficacy Of Cord Blood Cell Therapy For Cerebral Palsy.” Stem Cells and Development 24.19 (2015): 2259-2268. Web.
https://www.ncbi.nlm.nih.gov/pubmed/?term=Involvement+of+Immune+Responses+in+the+Efficacy+of+Cord+Blood+Cell+Therapy+for+Cerebral+Palsy

3. Lee, Young-Ho et al. “Safety and feasibility of countering neurological impairment by intravenous administration of autologous cord blood in cerebral palsy.” Journal of translational medicine vol. 10 58. 23 Mar. 2012, doi:10.1186/1479-5876-10-58
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369209/

4. Laskowitz, Daniel T. et al. “Allogeneic Umbilical Cord Blood Infusion For Adults With Ischemic Stroke: Clinical Outcomes From A Phase I Safety Study”. STEM CELLS Translational Medicine, vol 7, no. 7, 2018, pp. 521-529. Wiley, doi:10.1002/sctm.18-0008.
https://www.ncbi.nlm.nih.gov/pubmed/?term=Allogeneic+Umbilical+Cord+Blood+Infusion+for+Adults+with+Ischemic+Stroke%3A+Clinical+Outcomes+from+a+Phase+1+Safety+Study

5. Min, Kyunghoon et al. “Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial.” Stem cells (Dayton, Ohio) vol. 31,3 (2013): 581-91. doi:10.1002/stem.1304
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744768/

6. Romanov, Yury A. et al. “Human Allogeneic AB0/Rh-Identical Umbilical Cord Blood Cells In The Treatment Of Juvenile Patients With Cerebral Palsy.” Cytotherapy 17.7 (2015): 969-978. Web.
https://www.ncbi.nlm.nih.gov/pubmed/?term=Human+allogeneic+AB0%2FRh-identical+umbilical+cord+blood+cells+in+the+treatment+of+juvenile+patients

7. Sun, Jessica et al. “Autologous Cord Blood Infusion For The Treatment Of Brain Injury In Children With Cerebral Palsy.” Blood 126.23 (2015): 925-925. Web.
http://www.bloodjournal.org/content/126/23/925?sso-checked=true

8. Sun, Jessica M. et al. “Effect Of Autologous Cord Blood Infusion On Motor Function And Brain Connectivity In Young Children With Cerebral Palsy: A Randomized, Placebo-Controlled Trial.” STEM CELLS Translational Medicine 6.12 (2017): 2071-2078. Web.
https://www.ncbi.nlm.nih.gov/pubmed/?term=Effect+of+Autologous+Cord+Blood+Infusion+on+Motor+Function+and+Brain+Connectivity+in+Young+Children+with+Cerebral+Palsy%3A+A+Randomized%2C+Placebo-Controlled+Trial

9. Ying, L. “Safety Analysis Of Umbilical Cord Blood Stem Cell Transplantation Combined With Nerve Growth Factor In The Treatment Of Cerebral Palsy In Children.” Chinese Journal of Tissue Engineering Research (2014): n. pag. Print. (link unavailable)