Four Ways Cord Blood Can Help Ischemic Stroke Patients
Why Choose CBC Health’s Stroke Recovery Treatment?
CBC Health is setting the standard for cord blood treatments to treat ischemic strokes. CBC Health only uses allogeneic (donated) cord blood which delivers above-average stem cell counts, as high as 50,000,000/kg body weight. CBC Health uses cord blood that is readily available, tested and stored by Europe’s second-largest private cord blood repository, Cord Blood Center Group (CBCG).
Allogeneic cord blood stem cells offer the following benefits when compared to autologous stem cells:
- Increased cell replacement
- Faster growth rates
- Tissue regeneration
- Neurotrophic Influence
- More therapeutic cells and proteins
- No history of tumorgenesis
- Readily available
A Natural Process for Healing
The complex process for improving brain function for stroke victims is being carefully researched in clinical studies across the world. When a brain area suffers a stroke, brain cells are killed creating an infarct. In this damaged region beneficial neurotrophins are eliminated, cell and vascular networks are damaged, inflammation occurs and immunity to diseases is weakened. Regenerative medicine seeks to reverse these processes. Researchers are learning how to help the brain heal itself by infusing a patient with cord blood that initiates Cell Replacement, provides a Neurotrophic Influence, promotes Immune Benefits and mediates Inflammation Reduction.
- Neural Repair
Cord blood contains progenitor cells that migrate to the stroke region in the brain which is called the infarct. When the cells have found the area that needs to be repaired, clinical researchers believe that progenitor cells differentiate into the appropriate cells along the penumbra, replacing cells that were damaged adjacent to the infarct. This process is called neurogenesis and it is a key factor for recovery.
Industry Support for Cord Blood Stem Cell Treatments
"What they (stem cells) do is to pump out very powerful growth factors, molecules and proteins that enhance native mechanisms of recovery, such as new synapses of neurons that are there, new blood vessels, and they have a very profound effect on modulating the immune system."
"Factors secreted by the transplanted (umbilical cord) cells were able to offer a neuroprotective effect. This may relate to the cells secreting vascular endothelial growth factors (VEGF), brain-derived growth factors (BDNF), and neurotrophin-3 (NT-3), all of which have potential benefits for the treatment of stroke."
"We believe that the primitive cells found in whole umbilical cord blood can help reduce swelling in the brain faster and rescue some brain cells that are on the brink of death."
Cord blood contains more than stem cells. It also contains several growth factors that aid in the proliferation, differentiation, and survival of healthy and weakened cells. They assist in rebuilding neural networks that have been damaged. FGF, BDNF, NGF, VEGF, NT3 and NT4 are key neurotrophic factors that enhance neurogenesis and promote neural plasticity.
Stem cells, especially oligodendrocyte (nerve) progenitor cells can modulate the immune response for individuals suffering from multiple sclerosis and ischemic strokes. Through paracrine (cell-to-cell) signaling, revived neural networks can then alert the immune system to respond to and eliminate pathogens in the brain. Cord blood also contains pluripotent cells that can regenerate all types of cells in diseased tissue and revive natural immune response mechanisms.
Stem cells play an important role in modulating inflammation after an infarct so that cells can be repaired. In studies, stem cells have migrated to regions of high inflammation and they have provided beneficial effects such as secreting neurotrophins to reduce brain inflammation or protect nerve cells.